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Anterior and inferior AMI involves a systolic reduction of both leaflets, with incomplete coaptation symmetrical pattern. As we have already indicated, mitral tenting was directly determined by apical and posterior PM displacement. Although most patients present remote infarction and ventricular remodelling with leaflet tethering, acute ischemia with regional wall motion abnormalities can lead to similar findings of leaflet tethering in some patients 4. The saddle-shape of the mitral ring is important for maintaining the normal stress of the leaflets. Loss of this shape and crushing of the ring due to remodeling of the LV results in increased stress of the leaflets with secondary MR As these changes are dependent on load conditions and the phase of the cardiac cycle, secondary MR is dynamic in nature 1.

The clinical expression of IMR assumes the sum of several cardiological factors and is usually asymptomatic The acute appearance secondary to PM rupture due to AMI is presented as acute heart failure and it is associated with significant hemodynamic deterioration.

However, progressive symptoms appear more frequently when the valvular lesion is severe and is manifested with the semiology of heart failure worsening when associated with left ventricular systolic dysfunction LVSD In the physical examination, the pansystolic murmur in the mitral focus irradiated to the left axillary line stands out, although the presence of this in the IMR varies widely according to the series studied and may be absent in up to half of the patients The intensity of the murmur has little relationship with the degree of regurgitation due to LVSD and left atrial LA compliance Therefore, in the presence of ischemic cardiomyopathy, the absence of regurgitation murmur should not discard the possibility of an underlying MR.

LV diameters, as well as 2D biplane volumes, or more accurately with 3D, as well as the sphericity index should be determined by echocardiography. In addition, echocardiography makes it possible to determine the extent and location of the segmental alterations and the parietal thinning of the LV, as well as the posterior and apical displacement of the posterior and anterior PM. Regarding the deformation of the mitral apparatus ring size, coaptation distance, leaflets angles and tenting area should be obtained in parasternal long axis in mesosystolic.

Even 3D-echocardiography allows us to assess the volume of tenting, which seems to provide advantages over 2D. The anterior leaflet in systole is below the posterior leaflet, which is also stressed, altering the coaptation.

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An eccentric jet of insufficiency appears, ipsilateral to the posterior leaflet, which goes to the posterior region of the LA Figure 2. This pattern is typical of inferior or inferolateral infarction. The symmetric closure is due to a global remodelling of the LV, with spheroidal shape and greater dysfunction. There is an apical displacement of both leaflets and the coaptation point, with greater dilation and flattening of the mitral annulus. The area and volume of tenting are greater than in the asymmetric pattern, being the origin and direction of the central regurgitation jet, by symmetrical affectation of both leaflets.

It is more associated with anterior infarction or multiple infarcts Figure 3. The presence of residual MR after surgery contributes to perpetuate the negative remodelling of the LV, associating more tethering of the mitral leaflets, generating a vicious circle that ends up increasing the severity of MR.

The presence of significant postoperative IMR is associated with worse prognosis than its absence Therefore, to prevent future complications it is necessary to avoid postoperative residual IMR Echocardiography allows the study of the viability of valve repair in IMR. There are several independent predictors of MR recurrence, mainly divided into 2 groups Table 1 18 :. On the other hand, a restrictive pattern of LV filling suggests very advanced myocardial dysfunction, giving greater negative remodelling after repair 20 ; severe dilatation of the LV is associated with a low probability of reverse remodelling after repair, leading to worse long-term results Other predictors are the presence of a jet of central regurgitation severe mobile restriction of both leaflets or complex jets of central and posteromedial origin TOE-3D may provide additional information in the surgical repair decision in IMR by providing a comprehensive visualization of the different components of the MV system Figure 4.

TTE is an excellent method to assess the mechanism and severity of IMR, although it presents some limitations. The following echocardiographic methods are used to assess the severity of MR 1. It is the most used and simple method in the evaluation of IMR. It assumes that the greater the severity of MR, the greater the size and extension of the jet within LA. However, it is imprecise, because the relationship between extension of the jet and severity of regurgitation is not direct, depending on many technical and hemodynamic factors.

Thus the interaction with a wall or valvular structure conditions its area, underestimating it Coanda effect. While central flows drag flux in its path producing overestimation, a large eccentric flow that is distributed through the posterior wall of LA goes in favour of severe IMR. Conversely, small flows that appear just behind the mitral leaflets indicate slight insufficiencies.

This method alone is not recommended to quantify the severity of the IMR, it should only be used to detect it.

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When more than just a small IMR central jet is observed, a more quantitative assessment is required. The VC is the width of the insufficiency jet after traversing the regurgitant orifice, so it represents its area. Its measurement must be carried out in two perpendicular projections to the line of commissures parasternal long axis or four-chamber apical axis.

Measuring the lowest VC, immediately distal to the regurgitant orifice and perpendicular to the flow. In the case of the IMR, the regurgitant orifice seems not to be circular, but rather more extended along the coaptation line. Furthermore, the Doppler image does not give an appropriate orientation of the 2D planes to obtain an accurate cross-sectional view of the VC.

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The VC seems to be less influenced by the load conditions of the LV and therefore, be more reproducible than the flow imaging colour methods. Intermediate VC values 3—7 mm require confirmation by quantitative methods. Many times, VC is obtained in eccentric jets. In case of multiple jets, the respective values of VC are not additive.

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The assessment of VC by 3D echocardiography is still reserved for research. Doppler volumetric method is a method used when the proximal isovelocity surface area PISA and the VC are not accurately applicable. The MR volume is obtained by calculating the difference between total stroke volume product of the mitral ring area by the time-velocity integral TVI of the LV input tract flow and the systemic stroke volume product of the LV outflow tract area by the LV outflow tract TVI.

It is time-consuming so it is not recommended as a first line method in the quantification of MR. Its calculation is inaccurate in the presence of significant aortic regurgitation. It is the most recommended quantitative method. It is recommended: four-chamber apical view to determine PISA, then align the flow with the ultrasound beam, adjust the gain and lower the wall filter, decrease the depth and reduce the sector size to increase the spatio-temporal resolution. Measure the PISA radius in mesosystolic, with the morphology of the flow as close to a hemisphere, in the first aliasing.

The effective regurgitant orifice area EROA is thus determined.


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This allows integrating the different severity indices, classifying MR in mild, moderate or severe Table 2 1. In secondary MR, the severity threshold is lower, 20 mm 2 and 30 mL, respectively, indicating a subgroup of patients with an increased risk of cardiovascular events. In IMR there is a dynamic variation of the regurgitant orifice, with early and late systolic peaks and mesosystolic descent.

Non-hemispheric PISA derived from eccentric jets, multiple or regurgitant or complex elliptical orifices may not be valid. The degree of MR could be underestimated, so a lower threshold is used in determining the severity of the functional MR. This is applicable in patients over 50 years of age.

go to link The TVI ratio, between the Mitral inflow Doppler and the aortic flow at the level of the rings in four-chamber vision, is an additional strong parameter in the assessment of MR severity. A ratio of 1.

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When MR severity increases there is a decrease in the S-wave velocity in the pulmonary vein flow determined by pulsed Doppler, being a sensitive but not very specific parameter of severity, since it can also appear in atrial fibrillation, ventricular dysfunction and increased LA pressure. In the most severe forms the S-wave can be reversed, being a specific parameter of severe MR. Speed itself is not a parameter of severe MR. In the eccentric MR it can be difficult to obtain a complete record, although the intensity of the signal is dense. IMR is a dynamic valvulopathy.

It is especially useful when there is a discrepancy between symptoms and severity of valve disease 6. ESE can identify symptoms and subclinical ischemic ventricular dysfunction in patients with asymptomatic IMR. Open Access. Online ISSN See all formats and pricing Online. Prices are subject to change without notice. Prices do not include postage and handling if applicable. Volume 13 Issue 1 Jan , pp. Volume 12 Issue 1 Jan , pp. Volume 11 Issue 1 Jan , pp.

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